Postdoctoral Research Associate Positionin Transcranial Ultrasound Localization Microscopy

Glial tumors are the most common primary brain tumors, with an incidence of approx. 50,000 to 100,000 per year. Patients for grade II diffuse gliomas are usually treated with an awake surgery to maximize the tumor resection while preserving neurological functions. However, it rarely allows complete removal of the tumor lesion which often infiltrates deep brain regions. Therefore, setting up a long-term follow-up by MRI is really required. The objective of project STRATUM, funded by the French Institute for Health and Medical Research (INSERM), is to develop and validate an ultrasound (US) imaging tool complementary to MRI perfusion for monitoring and diagnosing neo-angiogenesis of brain tumors to improve early diagnosis of lesion progression and to better adapt oncological treatments.
The project brings together 3 research labs:
•the Institute of Electronics, Microelectronics and Nanotechnologies (IEMN) Villeneuve d’Ascq, France.
•the IBrain group, INSERM, Tours University Hospital, Tours, France.
•the Institute of Research in Computer Science, Paul Sabatier University, Toulouse, France.
We have proposed to adopt a very recent concept of 3D Ultrasound Localization Microscopy (ULM) imaging for in-vivo brain tumors without skull opening which has never been done before. At IEMN, our specific task is to compensate for phase aberration due to through-skull transmission, that leads to shadow zones and innacuracy in localizing microbubbles. For that purpose, we have developed a phase-conjugation
approach based on a patient-specific numerical model of the skull.

More information on the link below.